Metabolic Failure Drives Ischemia Reperfusion Injury during Human Kidney Transplantation
نویسندگان
چکیده
منابع مشابه
Ischemia Reperfusion Injury in Kidney Transplantation
Ischemia and reperfusion have been a natural step during kidney transplantation. Impairment of blood flow starts with brain death due to severe hemodynamic disturbances in cadaveric donor. Clamping of renal artery causes an absolute ischemia during harvesting operation. Cold ischemia during allograft kidney storage may also cause additional ischemic damages (Southard et al. 1985; Ploeg et al.19...
متن کاملIschemia-reperfusion injury in kidney transplantation.
Ischemia-reperfusion injury to the kidney is a complex pathophysiological process that has importance during transplantation as it affects graft function and survival. It starts with the physiological changes associated with the death of the donor, including the direct effects of hypoxia and metabolic stress. The injury continues through the organ procurement and preservation procedures. Upon r...
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............................................................................................................. 6 Original publications ...................................................................................... 7 Abbreviations .................................................................................................... 8 Introduction ...............................................
متن کاملThymoglobulin and ischemia reperfusion injury in kidney and liver transplantation.
Since the beginning of organ transplantation, graft preservation has been one of the most important concerns. Ischemia reperfusion injury (IRI), which plays an important role in the quality and function of the graft, is a major cause for increased length of hospitalization and decreased long term graft survival. Among numerous attempts which have been made to minimize graft damage associated wi...
متن کاملIschemia/reperfusion injury in kidney transplantation: mechanisms and prevention.
Ischemia has been an inevitable event accompanying kidney transplantation. Ischemic changes start with brain death, which is associated with severe hemodynamic disturbances: increasing intracranial pressure results in bradycardia and decreased cardiac output; the Cushing reflex causes tachycardia and increased blood pressure; and after a short period of stabilization, systemic vascular resistan...
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ژورنال
عنوان ژورنال: European Journal of Vascular and Endovascular Surgery
سال: 2015
ISSN: 1078-5884
DOI: 10.1016/j.ejvs.2015.03.056